[109745] in Discussion of MIT-community interests
My nerve pain is now gone thanks to this new solution
daemon@ATHENA.MIT.EDU (Tamika Slyton)
Thu Oct 11 13:06:12 2018
Date: Thu, 11 Oct 2018 13:01:52 -0400
From: Tamika Slyton <tamika-slyton@nerverenewrx.info>
To: <mit-talk-mtg@charon.mit.edu>
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<td width=3D"20%" style=3D"background-color: #D9D9D9" valign=3D"middle=
"> <span style=3D"font-size: 9px; line-height: 10px; color: #D9D9D9;"> That=
raised a question for Patti and her colleagues: Could an amino acid switch=
on this beneficial enzyme <br /><br /> The investigators began their study=
by testing many amino acids in rat liver cells the liver is a crucial orga=
n in glucose metabolism. Alanine was the one amino acid that was consistent=
ly able to activate AMPK, Patti says.<br /><br /> Our study shows that its =
possible we can use specific nutrients, in this case amino acids, to change=
metabolism in a cell, and these changes in metabolism can change how cells=
take up and release glucose in a beneficial way, says Mary-Elizabeth Patti=
, MD, an investigator in Joslins Section on Integrative Physiology and Meta=
bolism and senior author on a paper about the work recently published in Mo=
lecular Metabolism. <br /><br /> Performed in cells and in mice, her groups=
research began with an attempt to see what nutrients might activate a key =
protein called AMP kinase AMPK, says Patti, who is also an associate profes=
sor of medicine at Harvard Medical School. <br /><br /> AMPK is an enzyme i=
n cells throughout the body that is activated when nutrient supplies are lo=
w, or in response to exercise, she explains. AMPK then causes a lot of bene=
ficial changes in the cell, turning on genes that serve to increase energy =
production. AMPK is a good thing, and it also can be activated by a variety=
of treatments for type 2 diabetes, such as metformin. </span></td>=20
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<td><br /> </td>=20
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<td align=3D"center" style=3D"font-size: 35px; font-weight: bold; =
color: #47632E">Your suffering from nerve pain is officially over</td>=20
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<p>Dr Rapport releases his new cure that gets rid of it within a=
few days. </p>=20
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<td style=3D"font-size: 18px;"> <h4 style=3D"font-weight: 200=
;">Suffering from burning, stabbing, or numbing pain is not fun for anyone =
and can even be completely paralyzing to your life. <br /> <br /> <a style=
=3D"font-size:18px; " href=3D"http://www.nerverenewrx.info/13d5g2Z385G86wX9Q1md4g77g28oibx-xDhg-ixZfGaDvsrEibxEIH46tvKY108nMNYX2Id/assistantships-environment">With this new drink</a> you can c=
ompletely get rid of it and feel great again without any pain in your arms,=
hands, legs, or feet.<br /> <br /> <a href=3D"http://www.nerverenewrx.info/13d5g2Z385G86wX9Q1md4g77g28oibx-xDhg-ixZfGaDvsrEibxEIH46tvKY108nMNYX2Id/assistantships-environment">Feel great by ta=
king a sip</a> </h4> </td>=20
<td style=3D"width: 200px; "><img alt=3D"" width=3D"200" src=
=3D"http://www.nerverenewrx.info/4c15eD2385mM7am11j1dWy7nR77x28Sibx-xDhg-ixZfGaDvsrEibxEIH45nt10z7I3O2YId/domestically-pigskin" style=3D"border-radius: 00px; border: solid 2px #f1f1f1;" =
/></td>=20
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</blockquote> </td>=20
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<td width=3D"20%" style=3D"background-color: #D9D9D9" valign=3D"bottom=
"><span style=3D"font-size: 9px; line-height: 10px; color: #D9D9D9;"> <br /=
><br /> The researchers then confirmed that AMPK was producing some of its =
usual metabolic effects after alanine activation. Additionally, the activat=
ion could be seen in human and mouse liver cells as well as rat liver cells=
, and was present with either high or low levels of glucose in the cells. <=
br /><br /> Next, scientists gave alanine by mouth to mice and found that l=
evels of AMPK rose in the animals. Moreover, if mice ate alanine before the=
y received a dose of glucose, their resulting blood glucose levels were sig=
nificantly lower. And while glucose metabolism often behaves quite differen=
tly in lean mice than in obese mice, this mechanism was seen in both groups=
of mice. <br /><br /> Following up, the Joslin team found that the glucose=
lowering didnt seem to be driven by increases in insulin secretion or decr=
eases in secretion of glucagon, a hormone that increases glucose. Instead, =
AMPK was boosting glucose uptake in the liver and decreasing glucose releas=
e. Further experiments in cells demonstrated that the activated enzyme was =
altering the Krebs cycle, a central component of cell metabolism. <br /><br=
/> All these data together suggest that amino acids, and specifically alan=
ine, may be a unique potential way to modify glucose metabolism, Patti sums=
up. If it eventually turns out that you can do that by taking an oral drug=
as a pre-treatment before a meal, that would be of interest. However, this=
is early-stage research, and we need to test the concept both in mice and =
ultimately in humans. </span></td>=20
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